The hospital was founded by Dr. Charles Campbell in 1948. At that time, there was a great amount of animal agriculture located throughout Healdsburg. The small animal portion of the practice was done in the hospital, and most of the large animal practice was accomplished by treating animals on the owners’ ranch. In 1969, Dr. David McCrystle joined the practice. At that time, there was still a large amount of farm animals being treated in Healdsburg. In addition to veterinary medicine, the practice supplied pregnant sheep to the University of San Francisco Medical School, where many of the current innovative in-utero surgery techniques on humans were developed by using these sheep. Gradually, as the numbers of dairies began decreasing, the number of pleasure horses that were being treated at the hospital began to increase.

In the late 1980s, the hospital was remodeled to allow better care and service for the ever-increasing amount of dogs and cats in the community.  Two examination rooms, a surgery room, and office space was added to the front of the building. The number of sheep, dairy cattle, backyard pigs and cows was on the decrease as more houses were being built, especially in Windsor. In the 1980s, the clients ranged in location from Ukiah on the north, Annapolis on the west, Napa on the East and Santa Rosa on the south. Dr. Bruce Bell joined the practice – he later left to start his own practice in Rohnert Park. Dr. McCrystle bought the practice when Dr. Campbell retired in 1979. Around this time, there was a drastic change in the animal population that the veterinary hospital served, including large and small animals. Dr. Witham served the practice for a few years at this time.

In 2005, the hospital was remodeled for the second time to provide more exam rooms and space to better treat the increasing number of patients. In 2004, Dr. Glenn Benjamin agreed to provide relief work, while in 2007 Dr. Roger Klein joined the practice part-time.

The veterinarians who have worked for Healdsburg Veterinary Hospital have always been actively involved with the community and have served on school boards, fair boards, and various community clubs.